کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049861 1543462 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
N-terminal region of α-synuclein is essential for the fatty acid-induced oligomerization of the molecules
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
N-terminal region of α-synuclein is essential for the fatty acid-induced oligomerization of the molecules
چکیده انگلیسی

Exposure of α-synuclein (αS), a major component of Lewy bodies in Parkinson’s disease, to polyunsaturated fatty acids (PUFAs) triggers the formation of soluble αS oligomers. Here, we demonstrate that PUFA binds recombinant αS protein through its N-terminal region (residues 2–60). In HEK293 cells, αS mutants lacking the N-terminal region failed to form oligomers in the presence of PUFA. The PUFA-induced αS oligomerization was accelerated by C-terminal truncation or Ser129 phosphorylation of αS; however, this effect was abolished by deletion of the N-terminus. The results indicate that the N-terminus of αS is essential for the PUFA-induced αS oligomerization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issues 25–26, 29 October 2008, Pages 3693–3700
نویسندگان
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