کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049913 1074146 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases
چکیده انگلیسی

Cdc25 phosphatases activate Cdk/Cyclin complexes by dephosphorylation and thus promote cell cycle progression. We observed that the peak activity of Cdc25A precedes the one of Cdc25B in prophase and the maximum of Cyclin/Cdk kinase activity. Furthermore, Cdc25A activates both Cdk1–2/Cyclin A and Cdk1/Cyclin B complexes while Cdc25B seems to be involved only in activation of Cdk1/Cyclin B. Concomitantly, repression of Cdc25A led to a decrease in Cyclin A-associated kinase activity and attenuated Cdk1 activation. Our results indicate that Cdc25A acts before Cdc25B – at least in cancer cells, and has non-redundant functions in late G2/early M-phase as a major regulator of Cyclin A/kinase complexes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 4, 18 February 2009, Pages 841–847
نویسندگان
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