کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049972 1074149 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glutathione redox regulates TGF-β-induced fibrogenic effects through Smad3 activation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Glutathione redox regulates TGF-β-induced fibrogenic effects through Smad3 activation
چکیده انگلیسی

Transforming growth factor-β (TGF-β) plays a pivotal role in the fibrogenic action involved in the induction of connective tissue growth factor (CTGF), extracellular matrix and fibroblast transformation. Smad3 mediates TGF-β signaling related to the fibrotic response. In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular glutathione level suppressed TGF-β1-induced phosphorylation of Smad3, while inhibiting TGF-β1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of α-smooth muscle actin. These data indicate that the intracellular glutathione redox status regulates TGF-β-induced fibrogenic effects through Smad3 activation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 2, 22 January 2009, Pages 357–362
نویسندگان
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