کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050054 1074151 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition
چکیده انگلیسی

C1q, the binding subunit of the C1 complex of complement, is an archetypal pattern recognition molecule known for its striking ability to recognize a wide variety of targets, ranging from pathogenic non self to altered self. DNA is one of the C1q ligands, but the precise region of C1q and the DNA motifs that support interaction have not been characterized yet. Here, we report for the first time that the peripheral globular region of the C1q molecule displays a lectin-like activity, which contributes to DNA binding through interaction with its deoxy-d-ribose moiety and may participate in apoptotic cell recognition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 20, 3 September 2008, Pages 3111–3116
نویسندگان
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