کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050588 | 1074175 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of the cytochrome P450 enzymes responsible for the ω-hydroxylation of phytanic acid
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of the cytochrome P450 enzymes responsible for the ω-hydroxylation of phytanic acid Identification of the cytochrome P450 enzymes responsible for the ω-hydroxylation of phytanic acid](/preview/png/2050588.png)
چکیده انگلیسی
Patients suffering from Refsum disease have a defect in the α-oxidation pathway which results in the accumulation of phytanic acid in plasma and tissues. Our previous studies have shown that phytanic acid is also a substrate for the ω-oxidation pathway. With the use of specific inhibitors we now show that members of the cytochrome P450 (CYP450) family 4 class are responsible for phytanic acid ω-hydroxylation. Incubations with microsomes containing human recombinant CYP450s (Supersomes™) revealed that multiple CYP450 enzymes of the family 4 class are able to ω-hydroxylate phytanic acid with the following order of efficiency: CYP4F3A > CYP4F3B > CYP4F2 > CYP4A11.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 16, 10 July 2006, Pages 3794–3798
Journal: FEBS Letters - Volume 580, Issue 16, 10 July 2006, Pages 3794–3798
نویسندگان
J.C. Komen, R.J.A. Wanders,