کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051079 | 1074190 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Ndc80 complex: Hub of kinetochore activity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Kinetochores are protein scaffolds coordinating the process of chromosome segregation in mitosis. Kinetochore components are organized in functionally and topologically distinct domains that are designed to connect the sister chromatids to the mitotic spindle. The inner kinetochore proteins are in direct contact with the centromeric DNA, whilst the outer kinetochore proteins are responsible for binding to spindle microtubules. The conserved Ndc80 complex is implicated in several essential outer kinetochore functions, including microtubule binding and control of a safety device known as the spindle assembly checkpoint. Here, we describe how current work is contributing to unravel the complex endeavors of this essential kinetochore complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 15, 19 June 2007, Pages 2862–2869
Journal: FEBS Letters - Volume 581, Issue 15, 19 June 2007, Pages 2862–2869
نویسندگان
Claudio Ciferri, Andrea Musacchio, Arsen Petrovic,