کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051516 | 1074202 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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چکیده انگلیسی
Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (ΔΨm) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of ΔΨm, underlying the presence of an increasing susceptibility of these organelles to damaging agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 521–525
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 521–525
نویسندگان
Erika Roat, Nicole Prada, Roberta Ferraresi, Chiara Giovenzana, Milena Nasi, Leonarda Troiano, Marcello Pinti, Elisa Nemes, Enrico Lugli, Ornella Biagioni, Mauro Mariotti, Luigi Ciacci, Ugo Consolo, Fiorella Balli, Andrea Cossarizza,