کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051572 1074204 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A conserved folding mechanism for PDZ domains
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
A conserved folding mechanism for PDZ domains
چکیده انگلیسی

An important question in protein folding is whether the folding mechanism is sequence dependent and conserved for homologous proteins. In this work we compared the kinetic folding mechanism of five postsynaptic density protein-95, disc-large tumor suppressor protein, zonula occludens-1 (PDZ) domains, sharing similar topology but having different primary structures. Investigation of the different proteins under various experimental conditions revealed that the folding kinetics of each member of the PDZ family can be described by a model with two transition states separated by an intermediate. Moreover, the positions of the two transition states along the reaction coordinate (as given by their βT-values) are fairly constant for the five PDZ domains.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 6, 20 March 2007, Pages 1109–1113
نویسندگان
, , , , , ,