کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051622 1074205 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction mode of a symmetric Trp-rich undeca peptide PST11-RK with lipid bilayers
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Interaction mode of a symmetric Trp-rich undeca peptide PST11-RK with lipid bilayers
چکیده انگلیسی

To better understand the mode of action of the antimicrobial peptide PST11-RK, we investigated its (1) bactericidal kinetics, (2) ability to induce bacterial membrane depolarization, (3) ability to bind to liposomes, (4) cis/trans prolyl isomerization, (5) lipid binding kinetics and (6) translocation across lipid bilayers. Our findings suggest that PST11-RK acts mainly by collapsing the cytoplasmic membrane potential; it first attaches to the membrane via cationic C- and N-terminal residues and then inserts its central hydrophobic residues into the lipid interior. In addition, it seems likely that cis/trans isomerization facilitates the translocation of PST11-RK across the lipid bilayer, where it may interact with secondary intracellular targets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 1, 9 January 2007, Pages 157–163
نویسندگان
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