کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051637 | 1074206 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss](/preview/png/2051637.png)
چکیده انگلیسی
A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 5, 20 February 2006, Pages 1251–1256
Journal: FEBS Letters - Volume 580, Issue 5, 20 February 2006, Pages 1251–1256
نویسندگان
Shigeki Oshima, Shin Onodera, Norio Amizuka, Minqi Li, Kazuharu Irie, Satoshi Watanabe, Yoshikazu Koyama, Jun Nishihira, Kazunori Yasuda, Akio Minami,