کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051754 | 1074209 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet](/preview/png/2051754.png)
In rodents a high-fructose diet induces metabolic derangements similar to those in metabolic syndrome. Previously we suggested that in mouse liver an unidentified nuclear protein binding to the sterol regulatory element (SRE)-binding protein-1c (SREBP-1c) promoter region plays a key role for the response to high-fructose diet. Here, using MALDI-TOF MASS technique, we identified an X-chromosome-linked RNA binding motif protein (RBMX) as a new candidate molecule. In electrophoretic mobility shift assay, anti-RBMX antibody displaced the bands induced by fructose-feeding. Overexpression or suppression of RBMX on rat hepatoma cells regulated the SREBP-1c promoter activity. RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet.
Journal: FEBS Letters - Volume 581, Issue 2, 23 January 2007, Pages 218–222