کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2052095 | 1074221 | 2006 | 6 صفحه PDF | دانلود رایگان |
Apoptosis represents a fundamental process during fetal/post-natal testis development. Therefore pro- and anti-apoptotic proteins are essential to regulate testis physiology. c-FlipL is a known inhibitor of caspase 8/10 activity; in this study its perinatal expression in mouse male germ cells was investigated. In testis sections and seminiferous tubule whole mount c-FlipL was found to be expressed in undifferentiated spermatogonia and to co-localize with germ stem cells markers. In vivo investigations in the vitamin-A deficient mouse, lacking differentiated germ cells, confirmed c-FlipL expression in undifferentiated spermatogonia. Further analyses showed Fas expression but no significant caspase 8/10 activity when c-FlipL was highly expressed. Altogether these data suggest that c-Flip may control the survival rate of undifferentiated spermatogonia.
Journal: FEBS Letters - Volume 580, Issue 26, 13 November 2006, Pages 6109–6114