کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052117 1074221 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
چکیده انگلیسی

The very first member of K+ channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically.OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183 ± 3 nM but did not affect any of the other channels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 26, 13 November 2006, Pages 6254–6258
نویسندگان
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