کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052170 | 1543466 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinct mechanisms underlie distinct polyphenol-induced neuroprotection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distinct mechanisms underlie distinct polyphenol-induced neuroprotection Distinct mechanisms underlie distinct polyphenol-induced neuroprotection](/preview/png/2052170.png)
چکیده انگلیسی
Glutamate excitotoxicity is mediated by intracellular Ca2+ overload, caspase-3 activation, and ROS generation. Here, we show that curcumin, tannic acid (TA) and (+)-catechin hydrate (CA) all inhibited glutamate-induced excitotoxicity. Curcumin inhibited PKC activity, and subsequent phosphorylation of NR1 of the NMDA receptor. As a result, glutamate-mediated Ca2+ influx was reduced. TA attenuated glutamate-mediated Ca2+ influx only when simultaneously administered, directly interfering with Ca2+. Both curcumin and TA inhibited glutamate-induced caspase-3 activation. Although Ca2+ influx was not attenuated by CA, caspase-3 was reduced by direct inhibition of the enzyme. All polyphenols reduced glutamate-induced generation of ROS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issues 28–29, 11 December 2006, Pages 6623–6628
Journal: FEBS Letters - Volume 580, Issues 28–29, 11 December 2006, Pages 6623–6628
نویسندگان
Keiko Yazawa, Takeshi Kihara, Huilian Shen, Yoshiari Shimmyo, Tetsuhiro Niidome, Hachiro Sugimoto,