کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052490 1074231 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats
چکیده انگلیسی

A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 20, 4 September 2006, Pages 4889–4894
نویسندگان
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