کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052501 1074231 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
P-glycoprotein effect on the properties of its natural lipid environment probed by Raman spectroscopy and Langmuir–Blodgett technique
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
P-glycoprotein effect on the properties of its natural lipid environment probed by Raman spectroscopy and Langmuir–Blodgett technique
چکیده انگلیسی

Behavior of P-glycoprotein (Pgp) natural lipid environment within the membrane of CEM cells expressing Pgp in the quantities varying from 0% to 32% of the total amount of all membrane proteins is described for the first time. Observed cooperative effect of Pgp-induced increase of membrane stability, decrease of the temperature of gel-to-crystal lipids transition and predominance of the lipid liquid crystalline phase at physiological temperatures should have an impact in development of multidrug resistance phenotype of tumor cells by favoring the Pgp intercellular transfer and Pgp ATPase activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 20, 4 September 2006, Pages 4953–4958
نویسندگان
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