کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052538 1074233 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi
چکیده انگلیسی

Processing of precursor proteins by the proprotein convertases is thought to occur mainly in the trans-Golgi network or post-Golgi compartments. Such cleavage is inhibited by the prosegment of the convertases. During our studies of the use of the inhibitory prosegment of PC1, we noticed that a construct containing the prosegment fused to the C-terminal secretory granule sorting domain was cleaved in the endoplasmic reticulum (ER) at a pair of basic residues, best recognized by furin and PC7. This was further confirmed when this construct was fused at the C-terminus with a KDEL ER-retention signal. This suggests that the convertases could cleave some substrates within the ER, possibly by displacing the inhibitory prosegment associated with them.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 25, 24 October 2005, Pages 5621–5625
نویسندگان
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