کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052776 | 1074240 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells
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کلمات کلیدی
CTGF, connective tissue growth factor - CTGF، عامل رشد بافت همبندPT, pertussis toxin - PT، سموم سوراخ دارS1P, sphingosine 1-phosphate - S1P، اسپینگوزین 1-فسفاتConnective tissue growth factor - فاکتور رشد بافت همبندChIP, chromatin immunoprecipitation - کروماتین ایمونوپرسیپیتاسیونGPCR, G protein-coupled receptor - گیرندههای جفتشونده با پروتئین جی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells](/preview/png/2052776.png)
چکیده انگلیسی
Connective tissue growth factor (CTGF) is induced by transforming growth factor-β (TGF-β) via Smad activation in mesangial cells. We recently reported that sphingosine 1-phosphate (S1P) induces CTGF expression in rat cultured mesangial cells. However, the mechanism by which S1P induces CTGF expression is unknown. The present study revealed that S1P-induced CTGF expression is mediated via pertussis toxin-insensitive pathways, which are involved in the activation of small GTPases of the Rho family and protein kinase C. We also showed by luciferase reporter assays and chromatin immunoprecipitation that S1P induces CTGF expression via Smad activation as TGF-β does.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 12, 9 May 2005, Pages 2576–2582
Journal: FEBS Letters - Volume 579, Issue 12, 9 May 2005, Pages 2576–2582
نویسندگان
Susumu Katsuma, Yoshinao Ruike, Takeaki Yano, Mai Kimura, Akira Hirasawa, Gozoh Tsujimoto,