کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052895 | 1074244 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mouse model of human infertility: Transient and local inhibition of endometrial STAT-3 activation results in implantation failure
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mouse model of human infertility: Transient and local inhibition of endometrial STAT-3 activation results in implantation failure Mouse model of human infertility: Transient and local inhibition of endometrial STAT-3 activation results in implantation failure](/preview/png/2052895.png)
چکیده انگلیسی
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 11, 15 May 2006, Pages 2717–2722
Journal: FEBS Letters - Volume 580, Issue 11, 15 May 2006, Pages 2717–2722
نویسندگان
Hitomi Nakamura, Tadashi Kimura, Shinsuke Koyama, Kazuhide Ogita, Tateki Tsutsui, Koichiro Shimoya, Takeshi Taniguchi, Masayasu Koyama, Yasufumi Kaneda, Yuji Murata,