کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053214 1074265 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Knock-down of LAR protein tyrosine phosphatase induces insulin resistance
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Knock-down of LAR protein tyrosine phosphatase induces insulin resistance
چکیده انگلیسی

To test the role of the leukocyte common antigen-related protein tyrosine phosphatase (LAR) as a regulator of insulin receptor (IR) signalling, an siRNA probe against LAR was developed. Knock-down of LAR induced post-receptor insulin resistance with the insulin-induced activation of PKB/Akt and MAP kinases markedly inhibited. The phosphorylation and dephosphorylation of the IR and insulin receptor substrate (IRS) proteins were unaffected by LAR knock-down. These results identify LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin. Moreover, the siRNA probe provides a molecular tool of general applicability for further dissecting the precise targets and roles of LAR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 14, 6 June 2005, Pages 3024–3028
نویسندگان
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