کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2053219 | 1074265 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response](/preview/png/2053219.png)
چکیده انگلیسی
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 14, 6 June 2005, Pages 3055–3062
Journal: FEBS Letters - Volume 579, Issue 14, 6 June 2005, Pages 3055–3062
نویسندگان
James C.B. Li, Davy C.W. Lee, Benny K.W. Cheung, Allan S.Y. Lau,