کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2053359 | 1074273 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Theoretical model of the interactions between Ca2+, calmodulin and myosin light chain kinase
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Theoretical model of the interactions between Ca2+, calmodulin and myosin light chain kinase Theoretical model of the interactions between Ca2+, calmodulin and myosin light chain kinase](/preview/png/2053359.png)
چکیده انگلیسی
Active Ca2+/calmodulin (CaM)-dependent myosin light chain kinase (MLCK) plays an important role in the process of MLC phosphorylation and consecutive smooth muscle contraction. Here, we propose a mathematical model of a detailed kinetic scheme describing interactions among Ca2+, CaM and MLCK and taking into account eight different aggregates. The main model result is the prediction of the Ca2+ dependent active form of MLCK, which is in the model taken as proportional to the concentration of Ca4CaM · MLCK complex. Wegscheider’s condition is additionally applied as a constraint enabling the prediction of some parameter values that have not yet been obtained by experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 20, 15 August 2005, Pages 4361–4366
Journal: FEBS Letters - Volume 579, Issue 20, 15 August 2005, Pages 4361–4366
نویسندگان
Aleš Fajmut, Milan Brumen, Stefan Schuster,