Initial description of primate-specific cystine-knot Prometheus genes and differential gene expansions of D-dopachrome tautomerase genes

• Revision of eutherian adenohypophysis cystine-knot genes
• Initial description of primate-specific Prometheus genes
• Revision of eutherian D-dopachrome tautomerase genes
• Revision of eutherian macrophage migration inhibitory factor genes
• Initial description of primate-specific D-dopachrome tautomerase differential gene expansions

Using eutherian comparative genomic analysis protocol and public genomic sequence data sets, the present work attempted to update and revise two gene data sets. The most comprehensive third party annotation gene data sets of eutherian adenohypophysis cystine-knot genes (128 complete coding sequences), and d-dopachrome tautomerases and macrophage migration inhibitory factor genes (30 complete coding sequences) were annotated. For example, the present study first described primate-specific cystine-knot Prometheus genes, as well as differential gene expansions of D-dopachrome tautomerase genes. Furthermore, new frameworks of future experiments of two eutherian gene data sets were proposed.