کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067111 | 1077882 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates
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کلمات کلیدی
FITCMICDAPITNFataxia telangiectasia mutated - Ataxia telangiectasia جهش یافته استPIKK - LIKKDNA damage - آسیبDNAinflammation - التهاب( توروم) Isocyanates - ایزوسیانات هاinterleukin - اینترلوکینGenomic instability - بی ثباتی ژنوم Apoptosis - خزان یاختهایATM - خودپردازtumor necrosis factor - فاکتور نکروز تومورFluorescence isothiocyanate - فلورسانس ایزوتیوسیاناتMethyl isocyanate - متیل ایزوسیانات
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates](/preview/png/2067111.png)
چکیده انگلیسی
The toxic response of cultured human colon epithelial-FHC cells to methyl isocyanate was investigated with regard to genomic instability. Qualitative and quantitative assessments of the extent of phosphorylation of DNA damage signaling factors such as ATM, γH2AX and p53, was increased in treated cells compared to controls. At the same time, many treated cells were arrested at the G2/M phase of the cell cycle, and had an elevated apoptotic index and increased inflammatory cytokine levels. Cytogenetic analyses revealed varied chromosomal anomalies, with abnormal expression of pericentrin protein. Analysis through ISSR PCR demonstrated increased microsatellite instability. The results imply that isocyanates can cause genomic instability in colonocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 33, Issue 6, June 2009, Pages 675-683
Journal: Cell Biology International - Volume 33, Issue 6, June 2009, Pages 675-683
نویسندگان
Pradyumna Kumar Mishra, Arpit Bhargava, Gorantla Venkata Raghuram, Suresh Kumar Jatawa, Nabila Akhtar, Saba Khan, Archana Tiwari, Kewal Krishan Maudar,