کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2068769 | 1078349 | 2012 | 10 صفحه PDF | دانلود رایگان |
Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. In Saccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved in Schizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 from S. pombe are not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.
► S. cerevisiae contains mRNA-specific activators controlling mitochondrial translation.
► Only a few of these factors seem conserved in the yeast S. pombe and in human.
► Conserved S. cerevisiae factors have an additional role e.g. in complex assembly.
► We find that the homologs in S. pombe fulfill only this complex assembly function.
► The complex assembly function is thus probably the ancestral one.
Journal: Mitochondrion - Volume 12, Issue 3, May 2012, Pages 381–390