کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2068871 1078362 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of mitochondrial ribosomal protein S29 (MRPS29) expression by a 5′-upstream open reading frame
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Regulation of mitochondrial ribosomal protein S29 (MRPS29) expression by a 5′-upstream open reading frame
چکیده انگلیسی

Mitochondrial ribosomal protein S29 (MRPS29) is a mitochondrial pro-apoptotic protein also known as death associated protein 3 (DAP3). Over-expression of MRPS29 has been reported to induce apoptosis in several different human cell lines while conferring resistance in glioma and Ataxia telangiectasia cells. These two contradictory reports led us to investigate the MRPS29-induced apoptosis further. Cyber searches of the EST databases revealed the presence of a splice variant of MRPS29 mRNA containing an upstream open reading frame (uORF) at the 5′ untranslated region (UTR). In this study, we confirmed the presence of this uORF using real-time RT-PCR and investigated its role in MRPS29 expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 10, Issue 3, April 2010, Pages 274–283
نویسندگان
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