کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2069109 1078372 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria
چکیده انگلیسی

Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 9, Issue 2, April 2009, Pages 86–95
نویسندگان
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