کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070329 1544495 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drugs that interact with cardiac electro-mechanics: Old and new targets for treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Drugs that interact with cardiac electro-mechanics: Old and new targets for treatment
چکیده انگلیسی
The concept of mechano-electrical feedback was derived from the observation that a short stretch applied to the beating heart can invoke an electrical response in the form of an afterdepolarization or a premature ventricular beat. More recent work has identified stretch-activated channels whose specific inhibition might help to treat atrial fibrillation in the near future. But the interaction between electrical and mechanical function of the heart is a continuum from short-term (within milliseconds) to long-term (within weeks or months) effects. The long-term effects of pressure overload have been well-described on the molecular and cellular level, and substances that interact with these processes are used in clinical routine in the care of patients with cardiac hypertrophy and heart failure. These treatments help to prevent lethal arrhythmias (sudden death) and potentially atrial fibrillation. The intermediate interaction between mechanical and electrical function of the heart is less well-understood. Several recently identified regulatory mechanisms may provide novel antiarrhythmic targets associated with the “intermediate” response of the myocardium to stretch.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 97, Issues 2–3, June–July 2008, Pages 497-512
نویسندگان
, , , , ,