کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070761 1544566 2016 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies
ترجمه فارسی عنوان
تحویل دو جانبه درمان های بیولوژیک برای درمان های سرطانی چندجملهای و هم افزایی
کلمات کلیدی
تحویل دوگانه، سرطان درمان، درمان های بیولوژیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Cancer causes > 8.2 million deaths annually worldwide; thus, various cancer treatments have been investigated over the past decades. Among them, combination drug therapy has become extremely popular, and treatment with more than one drug is often necessary to achieve appropriate anticancer efficacy. With the development of nanoformulations and nanoparticulate-based drug delivery, researchers have explored the feasibility of dual delivery of biological therapeutics to overcome the current drawbacks of cancer therapy. Compared with the conventional single drug therapy, dual delivery of therapeutics has provided various synergistic effects in addition to offering multimodality to cancer treatment. In this review, we highlight and summarize three aspects of dual-delivery systems for cancer therapy. These include (1) overcoming drug resistance by the dual delivery of chemical drugs with biological therapeutics for synergistic therapy, (2) targeted and controlled drug release by the dual delivery of drugs with stimuli-responsive nanomaterials, and (3) multimodal theranostics by the dual delivery of drugs and molecular imaging probes. Furthermore, recent developments, perspectives, and new challenges regarding dual-delivery systems for cancer therapy are discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 98, 1 March 2016, Pages 113–133
نویسندگان
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