کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070809 1544568 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening
ترجمه فارسی عنوان
مهندسی بافت مایکروویو قلب: سیستم های میکرو فیزیولوژی چند سلولی برای غربالگری دارو؟
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

The ability to accurately detect cardiotoxicity has become increasingly important in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes, researchers have explored their use in creating an in vitro drug screening platform. Recently, there has been increasing interest in creating 3D microphysiological models of the heart as a tool to detect cardiotoxic compounds. By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening. This review aims to provide an overview on the progress made in creating advanced models of the human heart, including the significance and contributions of the various cellular and extracellular components to cardiac function.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 96, 15 January 2016, Pages 225–233
نویسندگان
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