کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071233 1078733 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fast-Scan DSC and its role in pharmaceutical physical form characterisation and selection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Fast-Scan DSC and its role in pharmaceutical physical form characterisation and selection
چکیده انگلیسی

Conventional rate Differential Scanning Calorimetry (DSC) has been used for many years as a tool in the analysis of pharmaceutical materials. In recent years an extension of the technique to include fast heating and cooling rates has become more prevalent. Broadly termed Fast-Scan DSC, this review examines the current applications of this technique to the characterisation and selection of pharmaceutical materials. Its increasing use encompasses the characterisation of amorphousness in crystalline materials, the characterisation of polymorphs and polymorphic transitions, the solubility of drugs in polymers, and characterisation of dosage forms. Notwithstanding the advantages of analytical speed in analytical turnover, the review emphasises the advantages of Fast-Scan DSC in its sensitivity which allows the separation of overlapping thermal events, the reduction it provides in degradation during the scanning process and its role in determining solubility in waxy and polymeric based systems.A comparison of the uses of Fast-Scan DSC to modulated DSC techniques and localised thermal analysis is also given.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 64, Issue 5, April 2012, Pages 422–430
نویسندگان
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