کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2071414 | 1078747 | 2010 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Methods to assess stem cell lineage, fate and function Methods to assess stem cell lineage, fate and function](/preview/png/2071414.png)
Stem cell therapy has the potential to regenerate injured tissue. For stem cells to achieve their full therapeutic potential, stem cells must differentiate into the target cell, reach the site of injury, survive, and engraft. To fully characterize these cells, evaluation of cell morphology, lineage specific markers, cell specific function, and gene expression must be performed. To monitor survival and engraftment, cell fate imaging is vital. Only then can organ specific function be evaluated to determine the effectiveness of therapy. In this review, we will discuss methods for evaluating the function of transplanted cells for restoring the heart, nervous system, and pancreas. We will also highlight the specific challenges facing these potential therapeutic areas.
Journal: Advanced Drug Delivery Reviews - Volume 62, Issue 12, 30 September 2010, Pages 1175–1186