کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071504 1078754 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Women and heart disease — Physiologic regulation of gene delivery and expression: Bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Women and heart disease — Physiologic regulation of gene delivery and expression: Bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease
چکیده انگلیسی

Ischemic heart disease (IHD) is the leading cause of death in the United States today. This year over 750,000 women will have a new or recurrent myocardial infarction. Currently, the mainstay of therapy for IHD is revascularization. Increasing evidence, however, suggests that revascularization alone is insufficient for the longer-term management of many patients with IHD. To address these issues, innovative therapies that extend beyond revascularization to protection of the myocyte and preservation of ventricular function are required. The emergence of gene therapy and proteomics offers the potential for innovative prophylactic and treatment strategies for IHD. The goal of our research is to develop therapeutic gene constructs for the treatment of myocardial ischemia that are clinically safe and effective. Toward this end, we describe the development of physiologic regulation of gene delivery and expression using bioreducible polymers and ischemia-inducible gene therapies for the potential treatment of ischemic heart disease in women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 61, Issue 10, 10 August 2009, Pages 863–870
نویسندگان
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