کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2075985 1079402 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Converting differential-equation models of biological systems to membrane computing
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Converting differential-equation models of biological systems to membrane computing
چکیده انگلیسی

This paper presents a method to convert the deterministic, continuous representation of a biological system by ordinary differential equations into a non-deterministic, discrete membrane computation. The dynamics of the membrane computation is governed by rewrite rules operating at certain rates. That has the advantage of applying accurately to small systems, and to expressing rates of change that are determined locally, by region, but not necessary globally. Such spatial information augments the standard differentiable approach to provide a more realistic model. A biological case study of the ligand–receptor network of protein TGF-β is used to validate the effectiveness of the conversion method. It demonstrates the sense in which the behaviours and properties of the system are better preserved in the membrane computing model, suggesting that the proposed conversion method may prove useful for biological systems in particular.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 114, Issue 3, December 2013, Pages 219–226
نویسندگان
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