کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2076295 | 1079436 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epigenetic landscape of interacting cells: A model simulation for developmental process
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Epigenetic landscape of interacting cells: A model simulation for developmental process Epigenetic landscape of interacting cells: A model simulation for developmental process](/preview/png/2076295.png)
چکیده انگلیسی
We propose a physical model for developmental process at cellular level to discuss the mechanism of epigenetic landscape. In our simplified model, a minimal model, the network of the interaction among cells generates the landscape epigenetically and the differentiation in developmental process is understood as a self-organization. The effect of the regulation by gene expression which is a key ingredient in development is renormalized into the interaction and the environment. At earlier stage of the development the energy landscape of the model is rugged with small amplitude. The state of cells in such a landscape is susceptible to fluctuations and not uniquely determined. These cells are regarded as stem cells. At later stage of the development the landscape has a funnel-like structure corresponding to the canalization in differentiation. The rewinding or stability of the differentiation is also demonstrated by substituting test cells into the time sequence of the model development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 101, Issue 3, September 2010, Pages 156-161
Journal: Biosystems - Volume 101, Issue 3, September 2010, Pages 156-161
نویسندگان
Motoki Nakagawa, Osamu Narikiyo,