کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2076428 | 1079444 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of 10-11Â bp periodicities of eukaryotic DNA sequence in nucleosome positioning
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of 10-11Â bp periodicities of eukaryotic DNA sequence in nucleosome positioning Role of 10-11Â bp periodicities of eukaryotic DNA sequence in nucleosome positioning](/preview/png/2076428.png)
چکیده انگلیسی
10-11Â bp repeating patterns of the particular dinucleotides were suggested in positioning nucleosomes in eukaryotes. In order to assess the role, the 10-11Â bp periodicities of the dinucleotides were examined both in human well-positioned nucleosome DNA sequences and in promoter DNA sequences of eight species. Our results indicated that the periodical occurrence of the particular dinucleotides correlates to positioning nucleosome. The signals of 10-11Â bp periodicities are more pronounced in the nucleosome DNA sequences than in the linker DNA sequences. Near the transcription start site, the signals reveal a similar feature that the nucleosome organization exhibits. But, it seems that the species do not share the same dinucleotides patterns. Furthermore, the dinucleotides patterns are dominant at the specific region of genome, indicating their diverse roles in forming and organizing nucleosomes. Moreover, the 10-11Â bp periodicities signals near the translation start negatively correlate with gene expression, demonstrating a vital role in transcription regulation. Our study reveals some details about the roles of DNA sequence in positioning nucleosomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 105, Issue 3, September 2011, Pages 295-299
Journal: Biosystems - Volume 105, Issue 3, September 2011, Pages 295-299
نویسندگان
Hongde Liu, Shuhai Lin, Zongwei Cai, Xiao Sun,