Analysis of Sodium Benzoate Biotoxicity using Atomic Force Microscope

Atomic force microscope (AFM) was used to study the biotoxicity of food preservative sodium benzoate (SB) at the single cellular level. After treatment with SB at different concentrations and interaction time, lymphocyte morphology and membrane ultrastructure were analyzed visually. As compared with the normal lymphocyte, the cell morphology and membrane significantly changed, and its ultrastructure was also complex. After treatment with SB, the Rp-v, Rq, Ra, and values were changed. The statistical analysis of lymphocytes after treatment with SB was studied, and its mechanism is discussed.