کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2081253 | 1545213 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human glial cell culture models of inflammation in the central nervous system
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Research into human central nervous system (CNS) disorders has traditionally focused on interconnecting neurons, thought to be the most important functional elements in the CNS. Consequently, animal models have developed as the central paradigm in CNS drug development. However, evidence is accumulating that suggests glial cells play a much more important role in health and disease in the CNS than has been previously acknowledged. Brain development, neurotransmission, inflammatory and neuroprotective pathways and blood–brain barrier functions rely on glial cells. It is also the case that human glial cell cultures adequately mimic in vivo glial cell behaviour, providing a novel and valuable tool for CNS drug discovery and development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 11, Issues 1–2, January 2006, Pages 74–80
Journal: Drug Discovery Today - Volume 11, Issues 1–2, January 2006, Pages 74–80
نویسندگان
Johannes M. van Noort,