کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2083653 1545348 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled ice nucleation in the field of freeze-drying: Fundamentals and technology review
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Controlled ice nucleation in the field of freeze-drying: Fundamentals and technology review
چکیده انگلیسی

In the scientific community as well as in commercial freeze-drying, controlled ice nucleation has received a lot of attention because increasing the ice nucleation temperature can significantly reduce primary drying duration. Furthermore, controlled ice nucleation enables to reduce the randomness of the ice nucleation temperature, which can be a serious scale-up issue during process development. In this review, fundamentals of ice nucleation in the field of freeze-drying are presented. Furthermore, the impact of controlled ice nucleation on product qualities is discussed, and methods to achieve controlled ice nucleation are presented.

Figure optionsDownload high-quality image (69 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 85, Issue 2, October 2013, Pages 214–222
نویسندگان
, ,