Overcoming instability and low solubility of new cytostatic compounds: A comparison of two approaches

Schematic representation of the respective CD-compound- and TPGS-micelles-compound formulations. The compounds are only partially incorporated in the CDs and they are not protected against fast chemical degradation. On the contrary, TPGS micelles incorporate the compounds completely in their core, protecting the quinolinone ring from oxidative hydroxylation.