کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2084478 | 1545387 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comparison of two- and three-dimensional models for the simulation of the permeability of human stratum corneum
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A comparison of two- and three-dimensional models for the simulation of the permeability of human stratum corneum A comparison of two- and three-dimensional models for the simulation of the permeability of human stratum corneum](/preview/png/2084478.png)
چکیده انگلیسی
The stratum corneum is the outermost layer of cells in mammalian epidermis. It is widely believed to play the key role for the barrier function of the skin. This study characterises how the cell geometry influences the permeability of the membrane. It is based on a diffusion model, which is evaluated using numerical simulation. Three different geometry concepts, i.e., ribbon, cuboid and tetrakaidekahedral type, in two and three space dimensions are compared. The results confirm that tetrakaidekahedral cells with an almost optimal surface-to-volume ratio provide a barrier, in which a minimal amount of mass is used very effectively. Additionally, the study supplies tools to quantify this and links the results to the theory of homogenization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 72, Issue 2, June 2009, Pages 332–338
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 72, Issue 2, June 2009, Pages 332–338
نویسندگان
Arne Naegel, Michael Heisig, Gabriel Wittum,