کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2087789 1080692 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo
چکیده انگلیسی

SummaryGuinea pigs were intoxicated intramuscularly with different doses of soman, and cholinesterase activities were determined in the blood, diaphragm and parts of the brain – the pontomedullar area, the frontal cortex and the basal ganglia. The time course of poisoning following low doses (1,3, 5 μg/kg) and a dose equal to 1×LD50 (28.5 μg/kg) were studied. The dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1–3 μg/kg, and, following administration of a dose of 5 μg/kg, statistically significant blood cholinesterase inhibition was demonstrated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Applied Biomedicine - Volume 9, Issue 1, 2011, Pages 35–41
نویسندگان
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