کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2101191 | 1083114 | 2007 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The LKB1 tumor suppressor kinase in human disease The LKB1 tumor suppressor kinase in human disease](/preview/png/2101191.png)
Inactivating germline mutations in the LKB1 gene underlie Peutz–Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabetes and in a significant fraction of lung adenocarcinomas. These observations have increased the interest towards signaling pathways of this tumor suppressor kinase. The recent breakthroughs in understanding the molecular functions of the LKB1 indicate its contribution as a regulator of cell polarity, energy metabolism and cell proliferation. Here we review how the substrates and cellular functions of LKB1 may be linked to Peutz–Jeghers syndrome and other diseases, and discuss how some of the molecular changes associated with altered LKB1 signaling might be used in therapeutic approaches.
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1775, Issue 1, January 2007, Pages 63–75