کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112711 1084416 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1
ترجمه فارسی عنوان
پروتئین پالمیتوئید شده غشاء 3، مهاجرت سلول های کارسینوم سلول های سرطانی را ترویج می دهد و تهاجم را از طریق متالوپروتئیناز ماتریکس تنظیم کننده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• MPP3 are overexpressed in HCC.
• MPP3 promoted HCC cell migration and invasion.
• MPP3 up-regulated MMP1.

Membrane associated guanylate kinase (MAGUK) family, has been extensively studied in cellular adhesion and signal transduction at sites of cell–cell contact. Recently, growing attention has been paid to its role in the initiation and progression of various cancers. However, its role in hepatocellular carcinoma (HCC) has been rarely investigated. In this study, we found that membrane palmitoylated protein 3 (MPP3), a member of MAGUK family, was significantly up-regulated in both high metastatic potential cell lines and clinical tissue samples of HCC, and the most significant increase was observed in the tumors invading the portal veins. Higher level of MPP3 correlated with poorer survival of patients with HCC. Forced expression of MPP3 significantly enhanced HCC cell migration and invasion, whereas knockdown of this gene inhibited this oncogenic effect. Mechanismly, we found that MPP3 promoted HCC cell migration and invasion via up-regulating matrix metalloproteinase 1 (MMP1). These findings indicate that MPP3 play an important role in HCC metastasis by promoting cell migration and invasion, suggesting that it may serve as a novel prognostic marker and molecular target for therapy of HCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 344, Issue 1, 1 March 2014, Pages 74–81
نویسندگان
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