کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112907 1084429 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of intestinal cancer stem cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Regulation of intestinal cancer stem cells
چکیده انگلیسی

Colorectal tumours harbour a sub-population of cells with stem like properties termed ‘cancer stem cells’, which are believed to ultimately drive cancer growth. This review discusses recent advances in our understanding of both normal and cancer intestinal stem cells, with emphasis on similarities and differences. Specifically we discuss the role of the Wnt, Notch and BMP pathways and their roles in both stem cell proliferation and differentiation. Furthermore we discuss the emerging role of microRNA and the influence of environmental factors such as tumour associated myofibroblasts and hypoxia on cancer stem cell regulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 338, Issue 1, 10 September 2013, Pages 120–126
نویسندگان
,