کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113107 | 1084442 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo](/preview/png/2113107.png)
چکیده انگلیسی
In the present study, the effect of a novel derivative of riccardin D (RD-N) against cancer cell lines was investigated in vitro and in vivo. We found that RD-N accumulated in the lysosomes associated with lysosomal swelling. As a result, the destabilized lysosomes induced cathepsins to release from the lysosomes into the cytosol and induced cell death which displayed features characteristic to both apoptosis and necrosis. In vivo tumor xenograft model indicated treatment of RD-N significantly reduced size and weight of the tumor compared with vehicles. These findings suggest RD-N could be a promising candidate for treatment of cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 329, Issue 2, 28 February 2013, Pages 207–216
Journal: Cancer Letters - Volume 329, Issue 2, 28 February 2013, Pages 207–216
نویسندگان
Yanyan Wang, Lining Wang, Zhongyi Hu, Yuan Ji, Zhaomin Lin, Huiqing Yuan, Mei Ji, Hongxiang Lou,