کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113898 1084505 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption
چکیده انگلیسی

Prostate-specific membrane antigen (PSMA), an established enzyme–biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSMA-targeted PDT resulted in rapid disruption of microtubules (α-/β-tubulin), microfilaments (actin), and intermediate filaments (cytokeratin 8/18) in the cytoplasm of LNCaP cells. The collapse of cytoplasmic microtubules and the later nuclear translocation of α-/β-tubulin were the most dramatic alternation. It is likely that these early changes of cytoskeletal networks are partly involved in the initiation of cell death.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 296, Issue 1, 1 October 2010, Pages 106–112
نویسندگان
, , ,