کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114018 1084512 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms
چکیده انگلیسی

In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. We identified a time window during which tumor oxygenation was improved, as a result of a combined effect on tumor blood flow and oxygen consumption. Consequently, the administration of S-nitrosocaptopril contributed to the increase in efficacy of radiation therapy, an effect that was not observed with captopril alone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 293, Issue 2, 28 July 2010, Pages 213–219
نویسندگان
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