کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114171 | 1084521 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation](/preview/png/2114171.png)
چکیده انگلیسی
Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 288, Issue 1, 1 February 2010, Pages 75–85
Journal: Cancer Letters - Volume 288, Issue 1, 1 February 2010, Pages 75–85
نویسندگان
Rai-Hua Lai, Ya-Wen Hsiao, Mei-Jung Wang, Huan-Yu Lin, Chew-Wun Wu, Chin-Wen Chi, Anna Fen-Yau Li, Yuh-Shan Jou, Jeou-Yuan Chen,