کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114340 1084531 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Down-regulation of αv integrin by retroviral delivery of small interfering RNA reduces multicellular resistance of HT29
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Down-regulation of αv integrin by retroviral delivery of small interfering RNA reduces multicellular resistance of HT29
چکیده انگلیسی

Since multicellular resistance (MCR) has been shown to be as adhesion-dependent, the role of αv integrin in MCR of HT29 was investigated in this paper. Down-regulation of αv integrin reduced MCR to oxaliplatin, but did not detectably change the drug sensitivity of monolayers. Down-regulation of αv integrin decreased phosphorylated NF-κB p65 and increased phosphorylated JNK2 in multicellular spheroids. Cell–cell adhesion and cell–cell junctions in multicellular spheroids resembled the in vivo situation. Since force, including adhesion, can activate αv integrin, cell–cell contact may contribute to activation of αv integrin, through which increasing phosphorylated p65 and decreasing phosphorylated JNK2 takes part in MCR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 284, Issue 2, 1 November 2009, Pages 182–188
نویسندگان
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